HST

Prerequisites: None
Offered: Longitudinal Course, August - June.
Location: HMS - Harvard Medical School (0)
Description: Description: Growth of the Physician-Scientist (GPS) is an integrated curriculum designed to support the personal and professional transformation from student to physician-scientist. The course builds on the themes of patient care, community, mentorship and role modeling, and reflective practice. Students will participate in a series of modules that are designed to expose them to the intersection of research and patient care.
Prerequisites: Enrollment priority provided to HST students; others by permission.
Offered: Fall.
Location: HMS - Harvard Medical School (0)
Description: Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of bioengineering are employed to promote analytical approaches to understanding the body's design. The embryology of major organ systems is presented, together with certain references to phylogenetic development, as a basis for comprehending anatomical complexity. Correlation clinics stress both normal and abnormal functions of the body; guest lecturers focus on current problems in organ system research. Cross listed with GSAS as MedSci250ab.
Offered: Year Long
Location: HMS - Harvard Medical School (0)
Description: This new course provides a hands-on introduction to the use of quantitative methods in medicine and health research. Each session will introduce a topic in quantitative techniques, provide an application to medicine, and lead participants through an approach to modeling in MATLAB. Problem sets applying the lessons learned in this course will be assigned throughout the preclinical curriculum. All participants are encouraged to download MATLAB before the start of the course.
Prerequisites: Anatomy & Pathology in HST curriculum or equivalent. Permission of instructor
Offered: Offered January.
Location: HMS - Harvard Medical School (0)
Description: The course covers growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues and response to stress, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and disease of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.
Prerequisites: General courses in Biology, Biochem & Physics; previous or concomitant courses in gross anatomy, molecular bio & immunology strongly recommended.
Offered: Fall.
Location: HMS - Harvard Medical School (0)
Description: The course provides an introduction to the organization, structure and function of normal cells and tissues (functional histology); the pathologic principles of cellular injury, inflammation, circulatory disorders and atherosclerosis, immunologic injury, infection, degenerative disease, neoplasia and environmental injury (pathology and the pathologic basis of disease); and the modern practice of pathology and pathologic research. Lectures, conferences, laboratory exercises and autopsy case studies are included. (Microscope required) Permission of instructor required for non HST students.
Prerequisites: General biology
Offered: Spring. Tues & Thurs 2/4/2020 - 5/14/2020.
Location: HMS - Harvard Medical School (0)
Description: This subject provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and modern diagnostic technologies. Topics include (1) general mechanisms of disease (inflammation, infection, immune injury, host response to foreign materials, transplantation, genetic disorders and neoplasia), (2) pathology of lipids, enzymes and molecular transporters, (3) pathology of major organ systems, and (4) review of diagnostic tools from invasive surgical pathology to non-invasive techniques such as diagnostic imaging and molecular pathology. The objectives of this course are achieved through a set of integrated lectures and laboratories, as well as a student-driven term project leading to a formal presentation on a medical, socioeconomic, or technological issue in human pathology.
Prerequisites: Biochemistry required; Genetics useful, molecular biology strongly recommended.
Offered: Fall.
Location: HMS - Harvard Medical School (0)
Description: The course will deal with the mechanisms of pathogenesis of bacteria, Mycoplasma, Chlamydia, viruses and the fungi. Special emphasis will be placed on events at the molecular level. Topics have been selected for intrinsic interest and will cover the demonstrated spectrum of pathophysiologic mechanisms. A course in molecular biology is strongly recommended as a prerequisite. (Microscope required)
Prerequisites: Permission of Course Director for non-HST students
Offered: Spring.
Location: HMS - Harvard Medical School (0)
Description: Students will study physiology and pathophysiology of the human endocrine system. The format of the course will include both didactic lectures on the various glandular systems and live presentation of clinical cases with relevant laboratory information. The cases serve to illustrate the pathophysiology and treatment of endocrine disease.
Prerequisites: Basic biochemistry, physiology and anatomy.
Offered: Fall.
Location: HMS - Harvard Medical School (0)
Description: This course is designed to give the student a clear understanding of the pathophysiology of the menstrual cycle, fertilization, implantation, ovum growth development, differentiation and associated abnormalities. Disorders of fetal development including the principles of teratology and the mechanism of normal and abnormal parturition will be covered, as well as ethical issues in reproductive science and significant medical issues affecting pregnant women such as pre-eclampsia and diabetes. Fetal asphyxia and its consequences will be reviewed with emphasis on the technology currently available for its detection. In addition the conclusion of the reproductive cycle, menopause, and the use of hormonal replacement will be covered. Emphasis on quantitative techniques, when applicable, including modern approaches to fetal surveillance and in vitro fertilization as well as prenatal diagnosis will be employed. Each lecture will be complemented by a brief clinical pathologic conference emphasizing relevant clinical applications of basic principles discussed in the lectures. Weekly thought questions will be assigned and a multiple choice final examination is given.
Prerequisites: General biochemistry and familiarity with principles of physiology, immunology, human anatomy, and molecular biology.
Offered: Second half Spring semester.
Location: HMS - Harvard Medical School (0)
Description: The course offers an intensive survey of the biology, physiology and pathophysiology of blood and the blood forming organs, with systematic consideration of hematopoiesis, blood cells, blood coagulation, blood groups, hematological malignancies, bone marrow transplantation, immunoglobulins and other plasma proteins. Emphasis will be given equally to basic scientific and clinical principles. Blood and bone marrow morphology are taught at the microscope. The goal of the course is to provide a comprehensive understanding of hematology for both the clinical and the basic scientist. (Microscope required)
Prerequisites: HT030 or Permission of C.D.
Offered: Spring.
Location: HMS - Harvard Medical School (0)
Description: The course covers normal and pathologic physiology of the heart and vascular system. Instruction will emphasize the quantitative and molecular biological aspects of cardiovascular hemodynamics, electrophysiology, gross pathology and clinical correlates of cardiovascular function in health and a variety of disease states. Special attention will be given to congenital, valvular, myocardial, and arteriosclerotic coronary heart disease. The case method is emphasized in tutorial sessions.
Prerequisites: Background in science and human anatomy.
Offered: Spring.
Location: HMS - Harvard Medical School (0)
Description: This course is designed as a first course in pulmonary biology in health and disease. The functional structure of the respiratory system and its physiology will be developed with the aid of quantitative models with relevance to human disease. The molecular basis of human disease, when known, will be reviewed and placed in the context of the aforementioned models. The use of diagnostic aids to establish the locus, type and magnitude of pathological processes will be examined.
Prerequisites: Permission of instructor
Offered: Spring.
Location: HMS - Harvard Medical School (0)
Description: The course presents the normal function of the kidney and its abnormal function in disease. The disorders of salt and water metabolism and of renal regulation of acid/base, potassium, calcium, blood pressure and renal pathology are included. Links between cell/molecular biology and renal disease are presented in special lectures. Problem sets and small group conferences/tutorials are emphasized.
Prerequisites: General courses in bio, organic & inorganic chem, physics & biochem recommended.
Offered: Fall.
Location: HMS - Harvard Medical School (0)
Description: The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs. The course is highlighted by selected patient presentations in clinic and mini-case format which demonstrate how an understanding of the basic and clinical sciences of gastroenterology is essential to rational diagnosis and therapeutic decisions. Throughout the course, formal lectures are given by the core faculty with some guest lectures by local experts. Selected seminars are conducted by students with supervision by faculty members.
Prerequisites: Permission of instructor
Offered: Fall.
Location: HMS - Harvard Medical School (0)
Description: HST 130/Neuro 200 is a comprehensive course in Neuroscience for HST medical students and graduate students. Basic principles of organization and function of the nervous system will be discussed with frequent reference to pathophysiology of neurological and psychiatric disorders. Combining pathophysiology with basic neuroscience should provide physician/scientists and Ph.D. candidates with a dynamic picture of the rapidly evolving field of neuroscience and the experimental process from which the picture is derived, and all students should emerge with a greater awareness both of the applications of their work in alleviating disease, and of the ways that disease can provide insight into basic scientific questions. The course will span modern neuroscience from molecular neurobiology to perception and cognition, and will include the following major topics: Anatomy and Development of the Brain; Cell Biology of Neurons and Glia; Ion Channels and Electrical Signaling; Synaptic Transmission, Integration, and Chemical Systems of the Brain; Sensory Systems, from Transduction to Perception; Motor Systems; and Higher Brain Function (Memory, Language, Affective Disorders). Cross listed with GSAS as NBio 200.
Prerequisites: Biochemistry and/or molecular biology.
Offered: Fall; 1-3pm, Tuesdays, starting September 10. Meets TMEC 128 (HMS) and 66-168 (MIT).
Location: HMS - Harvard Medical School (0)
Description: This course introduces students to a variety of topics in molecular medicine. The course is conducted as a seminar to study various human diseases and the underlying molecular, genetic or biochemical basis for the pathogenesis and pathophysiology of the clinical disorders. Lectures are presented by faculty experts engaged in current research in these fields, and seminars are conducted by the students with tutorials and supervision by faculty. Cross listed with GSAS: BCMP 218. Molecular Medicine
Offered: Monday 9:30-12:00
Location: HMS - Harvard Medical School (0)
Description: Intensive study of human biochemistry focusing on intermediary metabolism and structures of key intermediates and enzymes important in human disease for first-year students. Course provides basic understanding of human intermediary metabolism related to disease and therapeutic impact. Focus on four topics: lipids, amino acids, carbohydrates and nucleic acids, underscored with examples from diseases and clinical correlations. Summer sessions focus on the basics, while the fall course delves into more advanced topics and patient correlates.
Prerequisites: Permission of instructor.
Offered: Spring (Jan- March)
Location: HMS - Harvard Medical School (0)
Description: The object of the course is to teach students an approach to the study of pharmacologic agents. It is not intended to be a review of the pharmacopoeia. The focus will be on the basic principles of biophysics, biochemistry and physiology, as related to the mechanisms of drug action, biodistribution and metabolism. The course will consist of lectures and student-led case discussions. Topics to be covered include: mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interaction and substance abuse. Selected agents and classes of agents will be examined in detail.
Prerequisites: Background in biology and general biochemistry
Offered: Fall Meets Tuesdays 2-5pm
Location: HMS - Harvard Medical School (0)
Description: This course will provide a firm foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. The goal is to develop explicit connections between basic research, medical understanding, and the perspective of patients. During the course the principles of human genetics will be reviewed. Students will become familiar with the translation of clinical understanding into analysis at the level of the gene, chromosome and molecule, the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. The course will extend beyond basic principles to current research activity in human genetics.
Location: HMS - Harvard Medical School (0)
Description: Introduction to molecular diagnostic methods in medicine and relevant bioinformatics methods. Discussion of principles of molecular testing for diagnosis of somatic and germline diseases using FISH, genotyping, array CGH, next generation sequencing, and other technologies. Case conferences emphasize clinical correlation and integration of information from multiple diagnostic tests. Lectures, problem sets, and laboratory sessions will introduce key concepts in biological sequence analysis and provide experience with bioinformatics tools.
Offered: January T/Th 8:30-12:30pm
Location: HMS - Harvard Medical School (0)
Description:
Prerequisites: Biology and basic molecular biology suggested.
Offered: Fall.
Location: HMS - Harvard Medical School (0)
Description: Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases will be discussed with faculty tutors.
Prerequisites: Knowledge of calculus. Medical and graduate students only
Location: HMS - Harvard Medical School (0)
Description: This course will present the fundamentals of biostatistics and epidemiology with the aim of training students how to comprehend critique and communicate findings from the biomedical literature. In the first part of this course, students will learn how to assess the importance of chance in the interpretation of experimental data. Major topics covered include probability theory, normal sampling, chi-squared and t-tests, analysis of variance, linear regression and survival analysis, as well as how to perform elementary calculations using the statistical package STATA. In the second part this course, students will learn how to identify and prevent bias in observational studies. Students will learn about causal inference, types of bias (confounding, selection and information bias), and key study designs (randomized trials, cohort and case-control studies).
Prerequisites: Permission of course director; Introduction to Biostatistics and Epidemiology HT190 (suggested)
Offered: January Closed Spring 2020
Location: HMS - Harvard Medical School (0)
Description: As Olser famously said, "Medicine is a science of uncertainty and an art of probability." Most physicians recognize that medical decision making requires navigating a tangled web of uncertain diagnostic and therapeutic data, patient values, and costs. A growing literature regarding the cognitive limitations of physicians in the face of such complexity calls for more principled approaches medical decision making wherever possible. Many commonly encountered clinical problems can be fruitfully framed and analyzed quantitatively using tools from Probability Theory and Decision Analysis. Each participant in this course will pair with an experienced clinical mentor to analyze an unsolved contemporary medical diagnostic or decision problem using standard decision analysis software. This course will thus provide basic didactic sessions in combination with guidance through the process of identifying an appropriate problem, performing the analysis, and ultimately articulating the results in a publication.
Prerequisites: Intermediate biostatistics
Offered: 17-Jan
Location: HMS - Harvard Medical School (0)
Description: Clinical research is used to describe, predict, and make causal inferences. This course introduces the methods for the generation, analysis, and interpretation of data for clinical research. Major topics include the design of surveys, predictive models, randomized trials, clinical cohorts, and analyses of electronic health records. Students will learn to formulate well-defined research questions, to design data collection, to evaluate algorithms for clinical prediction, to design studies for causal inference, and to identify and prevent biases in clinical research. Familiarity with regression modeling and basic statistical theory is a pre-requisite. The course emphasizes critical thinking and practical applications, including daily assignments based on articles published in major clinical journals and the discussion of a case study each week. A key goal of the course is training students to comprehend, critique, and communicate findings from the biomedical literature.
Offered: Offered Fall and Spring terms
Location: HMS - Harvard Medical School (0)
Description: This course is intended for HST students and consists of research approved for academic credit by the Course Director. Hours are arranged with the research supervisor. May be repeated for credit.
Prerequisites: HST enrollment. Limited to MD candidates
Offered: January
Location: HMS - Harvard Medical School (0)
Description: Introduction To The Care of Patients provides students with clinical exposure to patients and physicians. Students observe physicians engaged in routine office medicine on a one/two student - one doctor basis. Opportunities to observe internists, psychiatrists, pediatricians, surgeons, orthopedists, and physicians caring for hospitalized patients are among the experiences students will encounter. An orientation session in January is followed by a longitudinal preceptorship experience throughout the spring term. The orientation is undertaken in the MIT Medical Department, and alumni physicians are the longitudinal preceptors.
Offered: Offered Fall and Spring terms
Location: HMS - Harvard Medical School (0)
Description: This course is intended for HST Year III and IV students and consists of research approved for academic credit by the Course Director. Hours are arranged with the research supervisor. May be repeated for credit. (Years I and II take HT199.0)
Offered: April-May
Location: MTAH - Mount Auburn Hospital (11)
Description: Anchoring Clinical Experience is a two-month clinical clerkship designed to ground the clinical skills learned in ICM. Held at Mount Auburn, an academic community teaching hospital, the clerkship will be divided into one month of outpatient/ambulatory medicine split between a primary care site as well as subspecialty clinics, and one month of inpatient medicine on the hospital wards. In addition to attending the daily hospital based teaching conferences for Mount Auburn internal medicine residents, students will have a case-based didactic curriculum that will focus on core topics in internal medicine. Finally, students will be expected to complete a case presentation with a focus on applying primary basic science and clinical trials literature into a discussion of clinical reasoning and decision-making.
Location: NONE - No Location
Description: This longitudinal course will allow students in research labs to maintain clinical connections while developing and refining clinical reasoning through discussion and dissection of New England Journal of Medicine Clinical Pathologic Conferences (CPCs). The course specifically targets MD students who are taking a "5th year" to do research as well as MD/PhD students who have already completed their qualifying exams. The format will involve students reading a case presentation before each class meeting, discussing the case presentation in class, arriving at a differential diagnosis, and discussing the NEJM expert's differential diagnosis and management, before evaluating the pathological diagnosis. The course will be taught by a neurologist and neuro-oncologist, Dr. Thomas Byrne, Clinical Professor of Neurology and HST, who is consistently cited as one of the best clinical faculty in the New Pathway neurobiology block. Although the cases will be principally neurological presentations, the clinical entities to be discussed involve a broad spectrum of diseases including inflammatory, toxic-metabolic, infectious, vascular, neoplastic, endocrine, genetic and degenerative, and students will, thereby, have a superior overview of multiple pathogenic entities over the course of a year. Each session will involve two hours in class in the early evening in the TMEC; the frequency will be twice a month to begin between 4:00 and 6:30 pm. The course is offered for credit with evaluations based on attendance and participation.
Prerequisites: Permission of course director (617) 667-1031
Offered: Spring
Location: HMS - Harvard Medical School (0)
Description: The barriers that have traditionally existed between disciplines are rapidly eroding. This is especially true in the field of endothelial cell biology. As a cell layer that traverses virtually every organ in the body, and one that is highly vulnerable to dysfunction and disease, the endothelium has far-reaching impact on human physiology and pathophysiology. This course provides an overview of the endothelium as a model system for understanding biological complexity in health and disease. Emphasis will be placed on: 1) mechanisms of endothelial cell heterogeneity, including genetic and microenvironmental determinants, 2) the role of endothelial cell function in physiology, including cell trafficking, hemostasis, barrier function, and vasomotor tone, and 3) the role of endothelial cell dysfunction in disease, including tumors, sickle cell disease, pulmonary hypertension, and xenotransplanation. Additional topics that will be discussed include novel proteomic and genomic strategies for mapping endothelial cell phenotypes, evolutionary (Darwinian) principles, and complexity theory.
Prerequisites: Year II standing. Pathophysiology. HST students only.
Offered: Spring.
Location: BWH - Brigham and Women's Hospital (23)
Description: This course teaches the necessary skills for acquiring a complete patient history and performing a thorough physical examination. Emphasis is placed on communicating patient findings, both in written form and oral presentations. Much of the instruction in this course is at the bedside. Lectures are oriented towards presenting the clinical findings associated with diseases, and are kept to a maximum of four per week, after the introductory module in Neuro-Psychiatry. Medical and Surgical Preceptors are assigned to their students for the entire semester. Students are evaluated by observed history-taking and physical examinations on patients. Human physiology is a course requirement.
Prerequisites: Required for 1st year MD/PhD Students.
Offered: July
Location: HMS - Harvard Medical School (0)
Description: The MD-PhD Program summer course (Investigations of Human Disease) is taken in the month preceding the first year of the program (M1) and is directed by Dr. Cammie Lesser. This course is required for all incoming MD-PhD Program students. This 4-week course will provide an in-depth analysis of recent advances in our understanding of human disease, as afforded by contemporary biomedical research in basic and social sciences. Topics vary from year-to-year as they reflect the expertise of a rotating group of HMS physician-scientist faculty chosen to present each year. Topics covered may include: developmental genetics and congenital birth defects, autoimmunity, complex human disease, genomics and bioinformatics, neurological disease, signal transduction, genomic technology, model organisms, cancer genetics, mechanisms of bacterial pathogenesis, history of science, medical anthropology, economics, and health policy.
Prerequisites: Classroom performance, interviewing skills, case write-ups, final exams.
Offered: MGH
Location: NONE - No Location
Description: MGH - Mass. General Hospital (3)
Prerequisites: Classroom performance, interviewing skills, case write-ups, final exams.
Offered: CAM
Location: NONE - No Location
Description: CAM - The Cambridge Hospital (6)
Prerequisites: Classroom performance, interviewing skills, case write-ups, final exams.
Offered: MMHC
Location: NONE - No Location
Description: MMHC - Mass. Mental Health Center (9)
Prerequisites: Year II standing.
Offered: Fall Term, Cannon, Castle, Holmes & Peabody; Spring term, HST only
Location: MULTI - Multi-site (J)
Description: This course provides an introduction to the clinical features, scientific understanding, and most effective treatments of the major mental health disorders that characterize medical practice. Psychiatric Disorders such as Mood Disorders, Schizophrenia, Anxiety Disorders, Trauma and Personality Disorders will be discussed in depth in both lecture formats and in small group discussions. Biweekly centralized sessions will feature didactic presentations and live or videotaped patient interviews. These sessions will alternate with smaller group sessions at clinical sites of the Departments of Psychiatry. At site visits, students will learn to assess patients with a range of psychiatric disorders. Patient write-ups will be reviewed. Material from the centralized sessions and from assigned readings from textbooks and original articles will be discussed. On-line self assessment questions will be posted throughout the course as study aids.