HMS-Division Of Medical Sciences


BP715.0  Molecular Approaches to Drug Action, Discovery and Design
Directors: Coen, Donald Mark
Prerequisites: Primarily for graduate students.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples...
BP715.0  Molecular Approaches to Drug Action, Discovery and Design
Directors: Coen, Donald Mark
Prerequisites: Primarily for graduate students.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples...
BP715.0  Molecular Approaches to Drug Action, Discovery and Design
Directors: Coen, Donald Mark
Prerequisites: Primarily for graduate students.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples...
BP715.0  Molecular Approaches to Drug Action, Discovery and Design
Directors: Coen, Donald Mark
Prerequisites: Primarily for graduate students.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Application of molecular, systems, and structural biology, genetics, genomics, enzymology, and chemistry to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples...
BP719.0  Behavioral Pharmacology
Directors: Bergman, Jack; Kangas, Brian D
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Sever 211
Time: 01/29/2019- 05/07/2019; TU; 3:00- 5:45 PM
Description: Introduction to CNS pharmacology and behavior in seminar format. Effects of psychomotor stimulants, antischizophrenics, opioid analgesics, and antianxiety agents on behavior. Emphasis on methodology and pharmacological analysis;...
BP722.0  Macromolecular NMR
Directors: Wagner, Gerhard
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall
Location: TBA
Time: TBA
Description: Theory and practice of modern methods of macromolecular structure determination using multi-dimensional NMR. Note: Given in alternate years. Cross listed with GSAS as BCMP 228. Classroom lectures on Mondays and Fridays. Wednesdays...
BP723.0  Molecular Biology
Directors: Loparo, Joseph John
Prerequisites: Intended primarily for graduate students familiar with basic molecular biology or with strong biology/chemistry background.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall
Location: Cannon Room, Building C
Time: 9/5/2018-12/10/2018; MWF; 10:45 - 12:15 PM
Description: Principles of Molecular Biology is a course organized around the Central Dogma of Biology with presentations covering fundamental aspects of DNA and RNA structure, their function and their interactions with proteins. The course...
CB704.0  Molecular and Systems Level Cancer Cell Biology
Directors: Sicinski, Peter
Prerequisites: General knowledge of biochemistry, molecular genetics, and cell biology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TMEC-250
Time: 01/25/2016- 04/27/2016; MW; 1:00- 2:30 PM
Description: Examines the molecular and systems basis of cancer including alterations in signal transduction, cell cycle, apoptosis and DNA repair. Offered alternate years with Cell Biology 212. Cross listed with GSAS as Cell Biology 211.
CB710.0  Developmental Biology: Molecular Mechanisms of Vertebrate Development
Directors: Flanagan, John G; Lassar, Andrew B.
Credits: 4.00 CREDITS (Basic Science)
Offered: Spring.
Location: TBD
Time: 01/28/2019- 05/15/2019; MW; 2:00- 4:00 PM
Description: Analyzes the developmental programs of frog, chick, zebra fish and mouse embryos with emphasis on experimental strategies for understanding the responsible molecular mechanisms. Principal focus of the course is the establishment...
CB713.0  Molecular Biology of the Cell
Directors: Moazed, Danesh
Prerequisites: Basic knowledge of biochemistry and genetics.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TBA
Time: TBA
Description: Cellular and organismal metabolism, with focus on interrelationships between key metabolic pathways and human disease states. Genetic and acquired metabolic diseases and functional consequences for specific organ systems. Lectures,...
CB721.0  Concepts in Development, Self-Renewal and Repair
Directors: Brack, Andrew Stephen; Drummond, Iain A.; Sahay, Amar
Prerequisites: Upper division Cell Biology or equivalent
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall
Location: TMEC L-007
Time: 09/6/2018- 12/7/2018; FRI; 2:00- 5:00 PM
Description: Explores developmental mechanisms through the life cycle, contrasting pluripotency and cell fate restriction in embryos and adult tissues. In depth analysis of in vivo approaches, with emphasis on tissue repair and self-renewal....
GN701.0  Principles of Genetics
Directors: Heiman, Maxwell G; Winston, Fred Marshall
Prerequisites: Intended for first-year graduate students.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall.
Location: Cannon Room, Building C
Time: 09/05/2018- 12/07/2018; MWF; 9:00- 10:20 AM
Description: An in-depth survey of genetics, beginning with basic principles and extending to modern approaches and special topics. We will draw on examples from various systems, such as Drosophila, C. elegans, mouse, human and bacteria. Note:...
GN703.0  Advanced Topics in Gene Expression
Directors: Buratowski, Stephen; Kingston, Robert Edward; Winston, Fred Marshall
Prerequisites: BCMP 200 and Genetics 201
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TMEC 128
Time: 01/24/2017- 05/09/2017; TU; 2:00- 5:00 PM
Description: Covers both biochemical and genetic studies in regulatory mechanisms. Small number of topics discussed in depth, using the primary literature. Topics range from prokaryotic transcription to eukaryotic development. Cross listed...
GN711.0  Genetics in Medicine-From Bench to Bedside
Directors: Newton-Cheh, Christopher Holmes; Sweetser, David Alan
Prerequisites: Genetics 201 or equivalent
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Simches Research Center, Room 3120, 185 Cambridge St., Boston, MA 02114
Time: 01/27/2017- 04/21/2017; FRI; 2:00- 5:00 PM
Description: Focus on translational medicine: the application of basic genetic discoveries to human disease. Will discuss specific genetic disorders and the approaches currently used to speed the transfer of knowledge from the laboratory...
GN724.0  Genotype to Phenotype: Epigenetics and Other Forms of Gene Regulation
Directors: Wu, Chao-ting
Prerequisites: Introductory course in genetics and biology, or permission of the instructor.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TBA
Time: TBA
Description: Explores lesser known forms of gene regulation, including dosage compensation, imprinting, transvection, RIP, paramutation, methylation, and nuclear compartmentalization, taking examples from prokaryotes, ciliates, fungi, plants,...
IM729.0  The Primary Immunodeficiencies
Directors: Terhorst, Cornelis
Prerequisites: Course in basic Immunology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: TBA
Time: TBA
Description: This course discusses the mechanisms that underlie the pathogenesis of genetically determined primary immunodeficiencies and selected autoimmune diseases. Evaluates the use of animal models for study and therapy of human disease...
MG705.0  Introduction to Virology
Directors: Abraham, Jonathan
Credits: 4.00 CREDITS (Basic Science)
Offered: Fall
Location: TMEC 447
Time: 09/05/2018- 12/5/2018; Mon 1:45PM – 3:15PM, Wed, 1:45PM – 3:45PM
Description: Introduction to virology. The lecture component reviews the basic principles of virology and introduces the major groups of animal viruses. Weekly discussion groups critically analyze selected papers from the literature Note:...
MG722.0  Social Issues in Biology
Directors: Beckwith, Jonathan Roger
Prerequisites: Some background in Genetics.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: NRB 833
Time: 02/07/2019- 04/25/2019; TH; 2:00- 5:00 PM
Description: Readings, discussion of social/ethical aspects of biology: history, philosophy of science; evolution vs. creationism; genetics and race; women and science; genetic testing; stem cell research; science journalism; genetics and...
MG723.0  Virology
Directors: Cunningham, James Morgan; Gewurz, Benjamin Elison
Prerequisites: Graduate standing and permission required.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: TMEC-426 (except Jan 23, 2017, in TMEC-328)
Time: 01/23/2017- 05/10/2017; MW; 2:30- 4:00 PM
Description: Literature based reading. Proposal writing. Course covers a broad range of topics: viral genetics, structure/replication, pathogenesis, evolution ("emerging viruses"), chronic infection, latency, innate and adaptive immunity,...
MG724.0  Proposal Writing
Directors: Whelan, Sean P.J.
Prerequisites: General background in biochemistry and virology.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Fall.
Location: TMEC 426
Time: 9/5/2018 - 11/7/2018; W; 1:45- 5:00 PM
Description: Students will write, present and evaluate research proposals in the areas of virus replication, viral pathogenesis and treatment and prevention of viral infections. Note: Offered jointly with GSAS as Virol 202.
NB713.0  Neurobiology of Disease
Directors: Kravitz, Edward Arthur
Prerequisites: Introductory neurobiology, biochemistry and genetics/ molecular biology are recommended.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring
Location: Goldenson Building Room 122
Time: 01/25/2016- 04/27/2016; Mon 6:00-8:30 p.m. and Wed 7:00-9:30 p.m.
Description: Monday sessions involve patient presentations and "core" lectures describing clinical progression, pathology, and basic science underlying a major disease or disorder. Wednesdays, students present material from original literature...
NB721.0  Neurophysiology of Central Circuits
Directors: Born, Richard T.; Wilson, Rachel
Prerequisites: Neurobiology 220.
Credits: 4.00 CREDITS (Non-Clinical Elective)
Offered: Spring.
Location: Goldenson building, Room 229
Time: 01/27/2017- 04/25/2017; MW; 9:00 AM- 11:00 AM
Description: Introduction to the physiology of circuits in the mammalian central nervous system. Topics include the auditory, somatosensory, olfactory, visual and oculomotor systems. Cross listed with GSAS as NBio 204.
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