Precision Medicine I: Genomic Medicine

Credits: 2.00 CREDITS (Non-Clinical Elective)
Directors: Kohane, Isaac Samuel
Prerequisites: Introductory computer science/programming class (or certification for CS50 online on HarvardX). AP Biology or college introductory biology
Offered: Fall
Open to Exclerks: No (HMS only)
It has been often repeated that the human genome project will transform medicine. In this course we will explore the ways in which genomics is indeed changing the processes of diagnoses and therapy but also the ways in which genomics recasts well-worn medical challenges in the context of the “big data” now generated across multiple measurement modalities in medicine. Like other scientific revolutions in measurement, but in its own unique way, genomics poses some practical and philosophical challenges about the nature of identity, disease and ethnicity. In the context of the economics of healthcare and the advent of precision medicine, these challenges require careful analytic and data-driven approaches which will be addressed in this course.
Learning Goals:
The goal of this course is to be able to answer the following questions in their fullest modern realization:
1) How does the advent of genomics change the practice of medicine?

2) How does one create a rational decision-making process around millions of variants in each human?

3) How does genomics inform us about the nature of disease, identity and ethnicity?
Students will be evaluated 50% based on their performance in class and 40% on their problem set results and 10% on the 2 page essay.
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