Pharmacology and Clinical Therapeutics

Credits: 4 CREDITS (Clinical Elective)
Sites: HMS
Director(s): James Rathmell, Mieke Soens
Prerequisites: HMS Principal Clinical Experience (Core Clinical Clerkships) or equivalent
Offered: September
Location: HMS - Harvard Medical School (0)
Open to Exclerks: No (HMS only)
Description: This course is primarily concerned with clinical therapeutics and therapeutic decision making in such areas as cardiology, infectious disease, transplantation, cancer chemotherapy, neurology, psychiatry, metabolism, and the critically ill. Emphasis is placed on clinical case discussions supplemented by more didactic lectures and panel discussions. While the orientation of the course is clinical, such pharmacologic issues as receptor interaction, pharmacokinetics and dynamics, drug interactions, specificity and selectivity will be analyzed in the context of specific organ system involvement and treatment of disease states. Issues in experimental therapeutics including analysis of the efficacy of new drugs, evaluation of clinical trials, and the design of clinical trials will also be discussed.
Incorporation of Basic Science Content and Evidence-Based Medicine:
The course is predicated on bridging what is known scientifically regarding the effects of therapeutics considering both efficacy and safety concerns. An evidence based medicine approach is used to support the date which is discussed in each therapeutic area. The course allows the student to translate from the bench knowledge accrued previously and apply it to the clinical states within each area of medicine covered by the presenters within the course structure.
Grade Criteria:
Honors with Distinction:
Only this grade is awarded for this course unless the work is unsatisfactory. The student must participate in class and given the time of year the course is offered, the student is only allowed to miss 3 classes to allow for time for internship interviews.
Any student who does not ask for permission with adequate justification to miss a class will receive an unsatisfactory. Furthermore, a student is only allowed to miss 3 classes during the four weeks to allow students the appropriate time to complete internship interviews. In addition, any student not consistently participating as ascertain by the course directors and/or presenter will be warned that they are bordering on poor performance and will be expected to increase class participation.