PA510.23

Embryopathology and Congenital Malformations

Sites: BWH
Director(s): Erik Alexander, Frederick Bieber
Prerequisites: HMS Principal Clinical Experience (Core Clinical Clerkships) or equivalent
Offered: Full time for one month. Open only March, April and May.
Location: BWH - Brigham and Women's Hospital (23)
Open to Exclerks: No (HMS only)
Description: This course is designed to fully integrate the principles of pathology, embryology, and medical genetics as they relate to human maldevelopment and unexpected pregnancy loss through first-hand study of case material, assigned reading, and individual tutorial instruction. Thus, the course provides a focus on an area often overlooked in more general courses in pathology or genetics. Topics include detailed study of the biology, embryology, pathology, and genetics of maldevelopment and spontaneous abortion in the human embryo, fetus, stillborn, and deceased newborn. Material will be presented via didactic tutorial instruction based on assigned readings from assembled syllabus, participation in autopsy, examination of microscopic material, attendance at departmental and interdisciplinary weekly conferences in pathology, cytogenetics and perinatal medicine, library research, and oral presentation of cases. Patient contact is provided in genetic counseling sessions in the Center for Women and Newborns. When appropriate, visits to see infants in the nursery will be arranged.
Incorporation of Basic Science Content and Evidence-Based Medicine:
First hand study of autopsy findings and laboratory findings are put in context through search of on-line data bases, study and discussion of published current literature and textbooks in order to arrive at diagnostic classification of findings. Assessment of rapid advances in medical and diagnostic genetics often determines the approach to individual patients and their laboratory testing.
Grade Criteria:
Honors with Distinction: daily attendance, exceptional ability to integrate basic science and clinical material in the workup of patients and their families in the context of medical genetics and pathology. Proactive and independent ability to learn. High motivation. outstanding performance in case presentations and oral exam. Honors: daily attendance, ability to think and work independently to integrate basic science and clinical data relevant to medical genetics and pathology casework high performance in case presentation and oral exam Satisfactory: daily attendance, progress in ability to independently integrate basic science and clinical data for workup of pathology casework, appropriate interactions with health care team and with patients, solid performance in case presentations and oral exam Unsatisfactory: uneven or poor attendance, lack of knowledge base or ability to integrate material, inappropriate personal interactions with health care team or with patients, lack of initiative, weak performance in case presentations and oral exam